BIOL 2153 Lecture Notes - Lecture 1: Dna Polymerase Iii Holoenzyme, Nucleosome, Okazaki Fragments
4 Nov 2020
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Structure of hiv: fraction of people that are missing receptor so can"t get hiv, figure 17. 11 hiv life cycle, very complex life cycle, reverse transcriptase is a very error prone enzyme. Watson and crick: two main lines of evidence to out dna structure, edwin chargaff, a=t, c=g, rosalind franklin and maurice wilkins. Space-filling model of dna: most like actual dna. Living in a dirty apartment and go to move you pack everything in boxes like mitosis. Chapter 9 notes: centromere spindle attachment region where spindle microtubules attach, telomeres are specialized to allow replication all the way to the end of the chromosome. If sequence didn"t matter and dna was completely broken down to nucleotides and each strand is a mixture. Results of automated dna sequencing: dideoxynucleotide sequencing = sanger sequencing (required reading, first human genome sequence cost billion dollars, technology keeps changing.
