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Lecture 2

BIOL 2160 Lecture Notes - Lecture 2: Pharmacodynamics, Nicotine, Bladder Cancer


Department
Biological Sciences
Course Code
BIOL 2160
Professor
Cross- Eyed
Lecture
2

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In Class Review
Explain electrochemical driving force and how it works
o Sum of electrical and chemical force
o For Na+ eq. potential is 55
o For K+ eq. potential is -94
Hypertonic: area that has more solute than another area
Hypotonic: area that has less solute than other area
Water always moves towards hypertonic
Pharmacokinetic has to do with your body breaking down drug and less once reach receptors
Pharmacodynamics is when receptors change
Direct communication involves ions and small molecules
Upregulation means making more receptors
Why does more acetylcholine receptors equal more smoking?
o when you smoke, make more receptors and cause more acetylcholine to be released
from presynaptic cell
o more receptors = more smoking
Protooncagenes are good, Oncagenes are what happens when they go bad and cause cancer
Second messengers are molecules inside the cells that when produced by the enzyme they can
activate multiple different pathways
QUIZ
1. At a membrane potential of -120 mV which force has stronger effect on K+?
a. Electrical
2. At a membrane potential of -70 mV which force has stronger effect on K+?
a. Chemical
3. At a membrane potential of 70 mV which force has stronger effect on Na+?
a. Electrical
4. The chemical force for Na+ always wants to move Na+ ____
a. Into the cell
5. The chemical force for K+ always wants to move K+ ____
a. Outside the cell
6. K+ crossing the membrane at -100 mV will make the membrane potential more ____
a. Positive
7. Na+ crossing the membrane at 40mV will make the membrane potential more ____
a. Positive
8. At a membrane potential of 10 mV, you would expect K+ to ______
a. Exit the cell
9. At a membrane potential of -60 mV, you would expect Na+ to ______
a. Enter the cell
10. One purpose of the Na+/K+ ATPase is to move Na+ _____ the cell
a. Out of
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