BIOL 4246 Lecture : BIOL 4246 Lecture 1 8 23 16 1
Document Summary
Genetic nomenclature rules for bacteria: phenotype -- set of observable traits, genotype -- genetic composition (discussed in terms of genes and alleles) Mutant -- organism whose genome differs from that found in nature (or differs from wild-type) Genome -- all genetic information of an organism. Genotype -- dna sequence of an organism that can be described. Mutation -- inheritable change in the dna sequence relative to the existing state; excludes genetically. Genotypic designation programmed dna rearrangements: 3-letter code related to phenotypic designation, all lowercase, italicized in print and underlined when written, use of + and - is optional, designate mutations, examples: Genotypes: trp, met, lys: another example: *trp/met/lys designate native state: dam gene refers to wild-type, dam implies mutation in dam gene. Tryptophan biosynthesis: capital letter after 3-letter code refers to mutation in specific gene (a,b,c, numbers are used to refer to different mutations in the same gene (alleles) trpa, trpb, trpc trpa1, trpa32.
