1. a. Consider the following sequences, which are pieces of a larger, independently folding polypeptide. Which sequence is more likely to form an alpha helix, and which is more likely to form a beta-hairpinâa two-stranded antiparallel beta-sheet in which the strands are separated by a turn?
Sequence A: I F I C T T G P N A T V I C V F V
Sequence B: M D R L M E A M A K L D H L L A E
b. How do the structures of the residues I, V, and T versus L and M contribute to the conformational preferences of these two sequences?
c. Which residues likely form the turn between the stands in the beta-hairpin? Why are these residues suited for this structure?
