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Lecture 28

PSYC 2000 Lecture Notes - Lecture 28: Acetyl-Coa, Citric Acid Cycle, Intermembrane Space


Department
Psychology
Course Code
PSYC 2000
Professor
stevengreening
Lecture
28

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Bio notes 11/07/2016
Glucose metabolism: C6H12O6 + O2 → 6CO2 +H2O + energy
Four steps in aerobic glucose metabolism:
Glycolysis - cytoplasm
Glucose → pyruvate
Formation of Acetyl CoA - matrix
Pyruvate → acetyl CoA
Krebs cycle - matrix
Production of NADH, FADH2, ATP
Electron transport chain - inner mitochondrial membrane
Production of many ATP
NADH and FADH2 give off electrons to ETC and become NAD+ and FAD
Chemiosmosis
Electrons accepted by O2
If O2 were no longer present, electrons would build up and ATP would not be
made
Each NADH pumps enough H+ into intermembrane space to phosphorylate 3 ATPs
Each FADH2 pumps enough H+ into intermembrane space to phosphorylate 2 ATPs
ATP , FADH2, NADH → least energy to most energy
Glucose has more energy than NADH
Cytoplasm - glycolysis - glucose lysed into 2 pyruvates - net yield= 2 ATP
Mitochondrial matrix -acetyl CoA and krebs cycle or citric acid cycle
10 NADH, 2 FADH2, 6 CO2 expelled as waste, 2 ATP
Inner membrane - ETC - O2 - Water and 32 ATP
Cyanide stops flow of electrons to o2
No ATP made
Carbon monoxide - CO, directly interferes w flow of electrons
Fe, Iron is what CN, OO, and CO bind to
Hemoglobin can’t bind to o2
O2 goes down
Too much ATP - body inhibits glycolysis; too little ADP
Feedback inhibition
Enzymes - substrates; products
Anaerobic - fermentation - lactic acid or lactate, or Alcoholic
Purpose of fermentation
If O2 is absent, then aerobic metabolism can’t proceed, but cell still needs energy
During glycolysis NAD+ → NADH
Run out of NAD, glycolysis can’t happen
NAD+ isn’t regenerated and is quickly used up
Fermentation regenerates NAD+
Lactate fermentation
Alcoholic fermentation (we don’t do)
Lactate fermentation - glucose - pyruvates - net yield of 2 ATP and 2 NADH
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