KNHS 6353 Lecture Notes - Lecture 1: Beta-Lactamase, Streptococcus, Staphylococcus

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19 Dec 2018
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Penicillins: natural penicillins, penicillinase resistant penicillin, broad-spectrum penicillins, extended-spectrum penicillins, natural penicillins. No anti-staph effect (penicillinase sensitive: benzyl-penicillin (short acting / penicillin g) Used mainly in prophylaxis against rheumatic fever in children with streptococcal pharyngitis. Main side effects: severe pain at site of injection. Drug of choice in streptococcal pharyngitis & tonsillitis. Methicillins cloxacillin dicloxacillin flucloxacillin in combination with ampicillin & amoxycillin. Against g+ve & g-ve (mainly on g+ve) No anti-staph effect (penicillinase sensitive) except if combined with penicillinase-inhibitors. Amoxycillins : emox ibiamox biomox - amoxcil. Ampiflox 250 & 500 caps: ampicillin + cloxacillin. 7 le: amoxycillin + penicillinase resistant penicillins. Flumox 250 susp 250 & 500 caps. 13 , 8 , 18 le: amoxycillin + dicloxacillin. 16 caps 11. 5 le: ampicillin + penicillinase inhibitor (sulbactam) 33 le: other common trade names : unictam - sulbin, amoxycillin + penicillinase inhibitor (clavulanic acid) Augmentin 375, 625 mg , 1 gm tab.

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