BS 182H Lecture Notes - Lecture 11: Pseudogymnoascus Destructans, White Nose Syndrome, Allylamine
17 Mar 2016
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Document Summary
Mitochondria uga coding for tryptophan: heterotrophic (like animals) but dissolve the medium they"re in and absorb it instead of a normal stomach, live in their food supply and grow into new food, multicellular but with cytoplasmic streaming to areas of rapid growth, fungi can"t grow without oxygen, so shipwrecks have preserved wood, have to digest wood in aerobic environments. Humungous fungus = largest and old living organism: yeast = single celled life form of fungus, fungus needs a damp environment, hyphae absorb nutrients that are dissolved in water, many kinds of fungus produce toxins (called mycotoxins) and enzymes that can disable, kill, and dissolve their food, fungus is injecting its host with toxins and digesting the host, homology to mammalian cells extends to biosynthetic pathways, similarity of fungal and mammalian cells creates a number of problems for designing drugs that are selectively toxic to fungal cells but not the human host, antifungal agents currently attack 1 of 4 targets.
