NEU 301 Lecture Notes - Lecture 24: Chemical Synapse, Action Potential, Cyclic Adenosine Monophosphate
Document Summary
Enhance the ability of incoming calcium to trigger fusion of synaptic vesicles with the membrane. build up of bulk ca2+ in presynaptic terminal. Generalization of an aversive response to a noxious stimulus to other non-noxious stimuli. 5-ht activates adenylyl-cyclase which in turn increases camp and then pka. Pka closes k+ channels leading to broader spikes and more ca2+ influx, and it also directly increases the release of neurotransmitter. Creb stimultes ubiquitin hydrolase which keeps pka persistently active by degrading pka"s regulatory subunit. This leads to regulation of activation of other genes which lead to structural changes such as growth of new synapses. Synaptic plasticity leads to changes in circuit function. Plastic changes can either be short-term, relying on post-translation modification of existing synaptic proteins, or long term, which require changes in gene expression, new protein synthesis and growth of new synapses.
