NEU 301 Lecture Notes - Lecture 35: Insulin Receptor, Bladder Cancer, Cell Membrane
Document Summary
Acetylecholine receptor action gated ion channel on muscle cells. The acetylcholine receptor (achr) is a ligand-gated ion channel for sodium ions. It is made up of five polypeptide subunits. When acetylcholine molecules (ach) bind to two of the subunits, the gate opens and na+ flows into the cell. This channel helps regulate membrane polarity action of insulin receptor. When insulin binds to the receptor, the receptor becomes activated and able to phosphorylate itself and other cytoplasmic proteins called insulin response substrates. Ras and studies with human bladder cancer cells. Bladder cancer cells have an abnormal form of a g protein called ras. The protein is permanently bound to gtp, causing continuous cell division. If the abnormal ras is inhibited, the cells stop dividing. Binding of one epinephrine molecule leads to production of many of camp. Ca2+ storage and mobilization in the cell activates protein kinase c, controls other channels, and stimulates secretion by exocytosis.
