NEU 301 Lecture Notes - Lecture 46: Sister Chromatids, Spindle Apparatus, Kinetochore
Document Summary
Apparatus composed of microtubules that will later separate the sister chromatids whose assembly occurs during prophase. Arrangement of microtubules in animal cell mitosis in which the centrioles extend a radial array of microtubules toward the nearby plasma membrane when they reach the poles of the cells. Second phase of mitosis in which the condensed chromosomes become attached to the spindle by their kinetochores and begin to move to the equator of the cell. Microtubule attachment- chromosomes attach to microtubules at the kinetochores. Each chromosome is oriented such that the kinetochores of sister chromatids are attached to the microtubules from opposite poles. Two basic mechanisms have been proposed to explain the force that moves chromosomes: Assembly and disassembly of microtubules provides the force to move chromosomes. Motor proteins located at the kinetochore and poles of the cell pull on microtubules to provide force. Third stage of mitosis in which the chromosomes align in the centre of the cell.
