NUR 259 Lecture Notes - Lecture 5: Ascending Limb Of Loop Of Henle, Loop Diuretic, Torasemide
Document Summary
Loop diuretics: loop: these medications work on the loop of henle in the nephron (specifically the thick ascending limb), diuretic: the goal is to increase urinary output by limiting how parts of the nephron reabsorb sodium. Hence, if we don"t reabsorb much sodium back into the blood, it will stay in the filtrate within the nephron, and this will keep more water in the filtrate too hence increasing urine production. Loops diuretics are the most powerful of all the types of diuretics when compared to thiazides and potassium-sparing diuretics. Loop diuretic generic medication names end with nide or mide. Examples: bumetanide, furosemide, torsemide with the exception of ethacrynic acid. They inhibit the na-k-cl (nkcc2) cotransporter protein found in the thick ascending limb of the loop of henle from transporting sodium, potassium, and chloride into the cell for reabsorption. Therefore, by inhibiting this transporter, it will prevent these ions (also called electrolytes) from being reabsorbed into the blood.
