BIO 375 Lecture Notes - Lecture 8: Liver Transplantation, Hepa, Dna Virus
Document Summary
Decreased bilirubin to intestine accumulation in blood jaundice. Hepatitis a (hep a) (+) ssrna virus. High prevalence in south america, africa, lower asia. Easiest to deal with, mostly supportive care for acute hep a. During acute infection viral concentration is highest in the stool. Contamination of fomites occurs (can survive in fresh and salt water for 12 months and dried feces for weeks) Transmission: blood and body fluids (semen, vaginal secretions) (std) If acquired at childhood carrier 200 times more likely to develop liver cancer. Vaccine available recombinant, inactivated, single antigen (often delivered with hep. Distribution: africa, europe, asia, south america, iceland. Hepatitis c (hep c) (+) rna virus, enveloped (cid:862) ile(cid:374)t epide(cid:373)ics(cid:863) many years for symptoms to appear (3. 9 million people infected in us) Transmitted by blood and blood products, needles, syringes, sexual contact (std again, intimate contact). Sofosbuvir and velpatasvir, a polymerase inhibitor, cures between 80 and 90%
