GN 301 Lecture Notes - Lecture 2: Colchicine, Acrosome, Cystic Fibrosis

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Published on 6 Dec 2017
School
NCSU
Department
Genetics
Course
GN 301
1.2 Cell Types, Chromosomes, Cell Division
Thursday, August 24, 2017
10:16 AM
Cell Biology
o Muscle
Can be striated or smooth
Strength and stretch
Want them to work together
o Blood
Work individually
RBC do not have a nucleus during development so it cannot reproduce
New ones grow from stem cells in bone marrow
o Nerve
Synapses
Organelles
o Nucleus
46 chromosomes
Have nuclear pores that allow movement in and out of the cell
o Ribosomes
Site of protein synthesis for cell
o ER
Rough: protein folding has ribosomes on it
Site of protein synthesis for transport out
Smooth: no ribosomes and lipid synthesis
o Golgi Apparatus
Starch and lipid production
Modify protein and transport it (thru vesicle)
Membrane bound
o Lysosomes
Breakdown bacteria and debris by use of their 40+ enzymes
Tay Sach's Disease
Autosomal recessive
Missing enzyme
Fatty substance builds up in brain and destroys tissue
Blindness, paralysis, death in 5 years
Mainly Jewish population
About 1/30 are carries as seem by genetic tests
Cultural mandated that two carriers not breed
Red Spot on the Eye
o Mitochondria
Break down nutrients to make energy
Passed from mother to child
Contains own special DNA
Leber's Hereditary Optic Neuropathy
Mitochondrial disorder
Sudden vision loss
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Document Summary

10:16 am: cell biology, muscle, can be striated or smooth, want them to work together. Strength and stretch: blood, work individually, rbc do not have a nucleus during development so it cannot reproduce, new ones grow from stem cells in bone marrow, nerve. Synapses: organelles, nucleus, 46 chromosomes, have nuclear pores that allow movement in and out of the cell, ribosomes, er. Site of protein synthesis for cell: rough: protein folding has ribosomes on it. Smooth: no ribosomes and lipid synthesis: golgi apparatus. Lost about 80% of vision: paralympic swimmer, plasma membrane, contains protein and glycoproteins aid in cell recognition. Sodium channels: ion channel, ability to detect pain: mutation: not feeling pain, potassium channels: control spikes in charge, also work as ion channel. Size of a : non-motile (does not move by self, but by cilia, almost mature prior to birth, 500,000 potential eggs but only 400 released.