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Lecture 17

GN 301 Lecture Notes - Lecture 17: Reverse Transcriptase, Helicase, Telomerase


Department
Genetics
Course Code
GN 301
Professor
Marian- Elizabeth B.Gardner
Lecture
17

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4.1 Cancer and Epigenetics
Thursday, November 16, 2017
10:10 AM
Introduction
o Mass of tissues that grow and divide limitlessly
No purpose
Error in cell cycle; mitosis spreads it
o 750k new cases
Characteristics
o Hyperplasia: uncontrolled cell division
o Anaplasia: cell is undifferentiated
o Metastasis: ability to move and establish tumors at other body sites
Types
o Leukemia
Large number of WBC made by bone marrow
Common In children
3.4%
o Lymphoma
Large number of lymphocytes made by spleen and lymph
5.4%
Hodgkin Disease
Cancer of the lymphatic system
o Carcinoma
Tumor of epithelial tissues
Ex: skin, colon, urinary system
85.3%
o Sarcomas
Embryonic mesoderm tissue
Ex: bone, muscle, fat
1.9%
o Miscellaneous
Mixed types; testicular or ovarian
4%
Causes
o Genetic
Single or polygenic
Chromosome aberration
Somatic cell mutation
Viruses
Epstein- Barr Virus
Burkitt’s Lphoa Liked; ifets B ells
Hepatitis Virus
Linked to liver cancer
HPV
Linked to cervical cancer
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