MB 351 Lecture 51: 15.8 Antimicrobial Drugs Methods
Document Summary
Skin application bc toxic (neosporin: vancomycin, glycopeptide, against gram-neg, toxic. Last resort in mrsa infections: vres appearing, opportunistic gram pos pathogens in hospital. Inhibit protein synthesis: targets specific part of ribosome, 80s in euk, 70s in prokaryotes, chloramphenicol inhibit formation of peptide bonds in polypeptide chain by binding with 50s, broad spectrum, easily duffisible, cheap. Serious side effects: stop bone marrow activity: aminoglycosides. Interfere with 30s shape so mrna read wrong: gram neg, hearing damage side effects, tetracycline. Interferes with trna attachment to 30s: used in animal feed, macrolides, macrocyclic lactone ring, gram pos, bind to 50s. Inhibit dna replication: affect both humans and animals so limited, quinolone. Inhibit gyrase which is used in replic: used for utis, resistance happens often, non toxic to humans, change membrane permeability. First synthetic but not used much due to antibiotics: treat utis, bacteriostatic.
