BIOS10115 Lecture Notes - Lecture 14: Subcutaneous Injection, Fetus, Dna Vaccination
16 Oct 2016
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Cell-mediated immunity: direct action of t cells to other cells displaying foreign antigens. Infected cells are killed by cytotoxic t cells: **t cells do not make antibodies, process: Atc (macrophage) enters lymphoid organ and unites with inactive t cell. Antigenic determinant recognized in association with mhc proteins. Another macrophage locates t helper cell and activates it (bind at cd4 site, interleukin-1 helps with activation) The activated t helper cell produces lymphokines to (cid:498)charge(cid:499) the t. The charged t cells divide, enlarge, and form a clone of cytotoxic t cell cells. These cells leave lymphoid tissues and travel to the infection site. Some memory t cells form from the division of the charged t cells, later distributed to tissues for long-term immunity. At infection site, cytotoxic t cells unite with infected cells after recognizing antigens. Cytotoxic cells release perforin and other substances that enter infected cells and destroy them. Types of t cells: immature t cell differentiates into specialized t cells:
