BIOS10115 Lecture Notes - Lecture 20: Salivary Gland, Chagas Disease, Antibody
16 Oct 2016
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Ppt #20: other microbial diseases (protozoa, fungus, worm) Infectious diseases caused by protozoa (single cell eukaryote: malaria, leishmaniasis, african sleeping sickness, chagas disease, giardiasis, amoebiasis, meningoencephalitis. Malaria: ancient disease, thought to be caused by (cid:498)bad air(cid:499, 1946- about 50,000 cases in us, now- about 1,500 cases and 5 deaths/yr. in us. Pesticides broke malaria cycle in us: but- 350 million cases and at least 1 million deaths/yr. worldwide. 3,000 children under 5 die per day (most susceptible) Still endemic in india, asia, central africa, south america, central. Plasmodium species- single cell protozoan (different strains) Cells travel to liver and replicate, develop, emerge from liver and infect rbcs. Development in rbcs results in death of rbcs, infection of new rbcs. Cycles of high chills and high fever: diagnosis and treatment: Diagnose with presence of plasmodium in blood smear. Connected malaria with mosquitos in ~ 1900. Quinine= first effective drug (from chichona tree) Multiple drug resistance is occurring (constant mutation)
