CHEM46497 Lecture Notes - Lecture 20: Ornithine, Lysine, Cp System

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Study guide chapter 18 amino acid oxidation and urea. Sources - diet, recycling of proteins, synthesis of non-essential amino acids. Uses make protein, use the nitrogen and carbon backbone to make other things, catabolize it. Ammonia reuse it to make amino acids or convert it to urea and excrete it. Ammonia comes from the amino groups of amino acids. Recall what peptidases are and where they can be found. Peptidases hydrolyze the peptide bonds that link amino acids together. Endopeptidase breaks amide bonds of non-terminal amino acids ones we"ve learned well chymotrypsin, trypsin, pepsin. Exopeptidase breaks amide bonds of terminal amino acids have peptidase at the end of their names. Pepsinogen is the zymogen (inactive) form of pepsin. Get h2o and co2 from all three. Amino acids you also get urea, uric acid, and salts. Glutamate alpha-ketoglutarate accepts amide group from amino acid and turns into glutamate can drop it off to form alpha ketoglutarate.

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