BIOL 2299 Lecture Notes - Lecture 18: Cd59
19 Apr 2016
School
Department
Course
Professor
Document Summary
Regeneration vs repair: regeneration: reactivation of the cellular pathways that were originally used to form the tissue/ organ, no scar tissue, repair: mechanisms to reduce blood lose, close wound, protect against infection, and replace lost cells in a mechanism different from that used in development, scar tissue. Regeneration in invertebrates: use totipotent or pluripotent cells that are retained in adult, due to expression of sox gene family, perhaps klf, polycomb group proteins that regulate epigenetics, piwi, and rnai protein, natural regeneration in mammals, liver has greatest regenerative capacity of all human organs i. ii. Need to have at least 25% of liver retained: liver functions: so many functions therefore live is important, processes toxic substances, synthesis of lipids, storage of glycogen, synthesis of bile for the body, regulator of plasma glucose level in the body, liver regeneration, all cells undergoing mitosis are adult, differentiated cells, not stem cells b.
