BIOL 2301 Lecture Notes - Lecture 5: Polyploid, Meiosis, Dosage Compensation

• School: Northeastern University
• Department: Biology
• Course: BIOL 2301
• Professor: Christopher Richardson

Document Summary

Haplotype uncovered byadeletionimustbe located inside the boundaries of i. ii. Chromosomal duplications transmitted together on the same chromosome iii. , ahaplotypecanbeasetoflinkedsingle nucleotide polymorphism ( snb) ,oraset a of characteristic repeatregionslshorttandemrepeatss. tn . Thcyaredifferentvariantsofapoymorphismlikeasnporssr: for example ,2 -3 alleles forcaohof 20-30 polymorphisms each at 20 - ii. Tandem duplications dnetounequalcrossoreriduetomispairingof homologous chromosomes during meiotic recombination mispairing crossover re. 30 locionyohromosomes : combine in 230-330 possible ways a genetic rearrangements in which the orderofgenesina chromosome: chromosome abnormalities are frequent in spontaneous abortions segment is reversed i. Major chromosome abnormalities : inversions donotatterthe genetic content change the linear. Aneuploidyinot having the same number of each chromo . producedinthecdl. Results from nondisjunction: inverted regions of chromosomes formloopsduringgcnepairingsynapsis) Resultoftrisomyrl ( three copies of chromosome 21 : chromosome. Aslongasthereisnocrossingoverintheloop , the chromosome willbeokthetwistihtoaloop allows genes to inversion chromosomes. On homologous matchup duringsynopsis loop resutsinacentricanddicentricchromatids inversion the region. Ifthecentromereisnotintheloop a b. c. d. e. likely toalignatmetaphaseplateimorelikelyto experience. Syndrome acentric anddicentricchromatids: pericentric inversion bi c.