BIOL 2301 Lecture Notes - Lecture 3: Abo Blood Group System, Amylopectin, Huntingtin
30 Aug 2016
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Obviously can"t self-fertilize and can"t make human test cross"s- so we look at family trees. Shaded if person is the phenotype of interest. Usually go left to right in terms of birth order (doesn"t matter because independent events) When we know heterozygous, can color in half: any one not colored in, doesn"t mean it"s not heterozygous, just means we know. Autosomal dominant traits late onset, rare fatal neurodegenerative progressive disease can get tested/screened for. Huntingtin makes a protein that doesn"t fold properly, aggregates, and causes neurodegeneration. Autosomal: not on sex chromosome: has equal likelihood of affecting men and women. Use two letters for this gene: hd is just one allele: hd hd is normal wildtype dominant recessive every affected individual has an affected parent. Mating between relatives: increased risk of homozygous recessive individuals. Dominance depends on the phenotype of the trait in question example: sbei starch gene.
