PSYC 3406 Lecture Notes - Lecture 20: Dopamine Hypothesis Of Schizophrenia, Synaptic Pruning, Meta-Communication

• School: Northeastern University
• Department: Psychology
• Course: PSYC 3406
• Professor: Ann Blumer

Document Summary

Early antipsychotic meds cause tremors in people with schizophrenia- similar to primary symptom in parkinsons; already knew parkinsons= low dopamine level connection, thus discovered this new relationship between. Schizophrenia and dopamine (dopamine hypothesis: also discovered that high doses of amphetamines cause symptoms of psychosis. How phenothiazines work: bind to d-2 receptors in brain; dopamine antagonists - prevent dopamine binding and neuron ring, have high # of dopamine receptors (may be why dopamine is overactive. Glutamate is also involved; pcp blocks glutamate receptors- also induces positive and negative psychotic symptoms. Exposure to viruses before birth in second trimester (ie in uenza) may also have a link/effect. Freud believed when the world is very stressful, people who develop schizophrenia regress to the earliest points in their development (primary narcissism) in which they recognize and meet only their own needs: pre-ego state . 1940s: frieda fromm-reichmann schizophrenogenic mother concept: blames mothers for being cold, uninterested and domineering.