PSYCH 212 Lecture 15: Lecture 15 & 16 Notes
10 Mar 2017
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Document Summary
Early life adversity associated with health problems stress research has focused on paternal maltreatment, early deprivation, or low. Early adversity sensitizes in ammatory system low ses associated with elevated in ammatory response to ex vivo microbial challenge. Early adversity potentiates crosstalk between threat circuitry and immune system brain-to-immune signaling immune-to-brain signaling. Endotoxin exposure enhances threat-related brain function facilitates dysregulated feedback loop between threat-related brain functioning and immune signaling. Ventral striatum, nucleus accumbens, caudate, and putamen are all part of the basal ganglia. Early life adversity attenuates reward-related neural activation maltreated children show reduced reward-related brain function in neural regions related to the ventral striatum. Depression associated with reduced ventral striatal/nucleus accumbent activation to reward cues. In ammation disrupts prefrontal maturation immune signals (microglia) play central role in prefrontal maturation. Chronic in ammation associated with reduced prefrontal volume and abnormal prefrontal development also associated with reduced structural integrity in pathways connecting prefrontal cortex with amygdala and striatum.
