CORE-UA 306 Lecture Notes - Lecture 9: Gene Expression, Filopodia, Cerebral Cortex
4 Apr 2017
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Problem: starts from one cell: development is conserved across species. Make a lot of neurons (*) tell them where to go (after make them, don"t make them all in place will get overwhelmed) (^) tell them what type of neuron to be (~) Organize their functions: group them into functions, refine that with experience. Gene expression dives patterning (is genetically coded), and is conserved across species. Born with more neurons than need, thus many neurons die early in development; some synapses formed early in development will be retracted while some new ones will form. ^: radial glia- how neurons know where to migrate from ventricular zone (where created) to cortical plate (begin forming cerebral cortex) Inside out migration of neurons (like pushing to the front of a crowd in a concert) ~: cell fate is heavily determined by location. Ectoderm: skin, cornea, lens of eye, etc. and nervous system.
