HUMNNTR 2210 Lecture Notes - Lecture 21: Myelin, Orange Juice, Wound Healing
9 Nov 2016
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Folate vs. folic acid: the synthetic form (folic acid) is the most potent form. Deficiency: red blood cell formation, megaloblastic anemia (large immature red cells) Lucy wills found that yeast extract could be used to treat megaloblastic anemia: neural tube defects (ntds, spina bifida) Opening in the spinal cord or brain. From maternal folate deficiency and genetic defect in folate. Rda: adults 400ug/day, higher for pregnant women, units are dietary folate equivalents. Sources: green leafy veggies, orange juice, grain products now fortified with folic acid. Upper level: 1000mg, refers to folic acid only, too much folate can mask b12 deficiency. Rda: adults 2. 4 ug/day, average exceeds rda, stored in liver, no upper level. Sources: made by bacteria, fungi, algae, animal products. Children vegans no body stores: megaloblastic anemia first symptom. Excess folic acid can mask this symptom: pernicious anemia (deadly) loss of neural function. Gums bleed, small hemorrhages, bruising: at risk: Sources: citrus fruits, potatoes, green peppers, broccoli, liver.
