MICR 2123 Lecture 19: Chapter 26
19 Nov 2016
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Document Summary
Pathogens can be classified as food-borne, airborne, blood-borne, or sexually transmitted. Understanding infectious disease requires knowledge of the organ system, the portal of entry, and the infectious organism. Patient histories are vital in diagnosing microbial diseases (farmers, travelers, campers, ) Zoonotic diseases are animal diseases accidentally transmitted to humans. Boils secrete coagulase that coat the organism with fibrin and hence evade immune response. Can produce toxic shock syndrome toxin (tsst), a superantigen. Scalded skin syndrome some strains make exfoliative toxin which is also a superantigen: streptococcus pyogenes (group a streptococci) Strep throat and immunological sequelae, such as rheumatic fever. Viral: several viruses can produce skin rashes, although their route of infection is usually through the respiratory tract. Successful lung pathogens possess attachment mechanisms and countermeasures to avoid various lung defenses. The mucociliary escalator is primary defense: bordetella pertussis (cause of whooping cough) adheres to tracheal epithelium and produces toxin that destroys lung cilia, mycobacterium tuberculosis (cause of tuberculosis)
