BIO 203 Lecture Notes - Lecture 15: Monoclonal Antibody, Adaptive Immune System, Passive Immunity

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Outline
The body’s defense system
Three lines of defense
Distinguishing self from nonself
Antibody-mediated responses and cell-mediated responses
Steps of the adaptive immune response
Active and passive immunity
Monoclonal antibodies
Problems of the immune system
The body’s defense system
The body generally defends you against anything that it does not recognize as
being part of or belonging inside you
Common targets of the defense system include
Pathogens
Disease-causing bacteria, viruses, prions, protozoans, fungi,
parasitic worms
Cancer cells
Once normal body cells whose genetic changes cause unregulated
cell division
Three lines of defense
Three strategies for defending against foreign organisms and molecules or
cancer cells
Physical and chemical surface barriers
Nonspecific
Keep foreign organisms or molecules out
Internal cellular and chemical defenses
Nonspecific
Attack any foreign organisms or molecules that have gotten past
the surface barriers
Immune response
Specific
Destroy specific targets and remember them
First line of Defense: physical and chemical barriers
Physical barriers
Skin
Nearly impenetrable
Waterproof
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