PYSO 001 Lecture 11: Pyso_01_-_Lecture_11
12 May 2020
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Factors that affect oxyhemoglobin dissociation: po2 (described above, ph: bohr effect, lower ph (e. g. 7. 2) affinity decrease (shifts curve to right), greater unloading. Active muscle more heat generated so more unloading of oxygen: 2,3-dpg (2,3-diphosphoglycerate, increase 2,3-dpg make deoxyhb more stable promotes oxygen unloading (shifts curve to right) 2,3-dpg is a byproduct of glycolysis in rbc. When o2 is low (e. g. high altitude or anemia) 2,3dpg produced in rbc. Shifts curve to right more oxygen unloading in tissues. Hemoglobin defect diseases: sickle cell anemia: under low partial pressure of oxygen, causes rbc to become sickle shaped and can"t pass well through capillaries, thalassemia: decreased synthesis of and chains. Co2 is a byproduct of aerobic respiration; produced by tissues. Three forms of carbon dioxide: dissolved gas ~10, bound to hb ~20, transported as hco3 (bicarbonate)~70% In plasma: slow, spontaneous combining of co2 + h2o to make carbonic acid.
