BB H 130 Lecture Notes - Lecture 19: Glucose Tolerance Test, Prediabetes, Metformin
Document Summary
Oral glucose tolerance test (ogtt: measures how well the body processes glucose, no food or drink 8-12 hours prior to test, drink glucose, blood is tested 2 hours later, high glucose level, potential diabetes. Us pop survey: increase between 1990-2000 in # of people diagnosed with diabetes, mean body weight is increasing too. Nurses health study: in 80s and 90s, result, bmi dm risk, asked nurses because they fill out forms all the time. Diabetes prevention program (dpp) - study of overweight people with prediabetes. Diabetes prevention program: evaluate if interventions can prevent t2dm, check for differences in effectiveness and safety, learn if effectiveness differs based on subject characteristics, 1995-2001, multicenter study, 3234 men and women, prediabetes, bmi > 25, overweight, obese. Lifestyle group: 30 minutes of moderate exercise 5 days/week, majority went on a walk, asked them to lose 5-10% body weight, eat lower fat diet, average weight loss, 7%
