B M B 221 Lecture Notes - Lecture 7: Anandamide, Asthma, Migraine

• School: PSU
• Department: Biochemistry and Molecular Biology
• Course: B M B 221
• Professor: Keating Steven

Document Summary

Basic structure: one or more phosphates, five carbon sugar. Uses: building blocks of dna and rna, role in energy metabolism, precursors for variety of compounds, including some alkaloids. Biosynthesis of adenine-containing nucleotides: de novo pathway, ribose-5-phosphate + atp 5-phospho-ribosyl-1-pyrophosphate (prpp) + amp, prpp imp. Prpp = core upon which the purine base is assembled. Sources of c and n atoms in purine base: 2 glutamines=2 ns, glycine= 2 cs, 1 n aspartate= 1 n. Final product=imp (inosine monophosphate), newly synthesized purine: imp + aspartate amp + fumarate. Aspartate: donates an nh2 to one of the purine rings. From amp, can make atp, nucleotides for dna, rna: salvage or recycling pathway. Uses existing adenine molecules, used to make amp, adp, atp. Class includes: caffeine, theobromine and theophylline. Methylated derivatives of xanthine and xanthosine (xanthine + ribose sugar) Imp + nad+ xanthosine + po4 + nadh. Imp oxidized using nad+ (nad+ reduced to nadh)