BIOL 141 Lecture Notes - Lecture 8: Hematopoietic Stem Cell, Bone Marrow, White Blood Cell
Document Summary
Amino acids, proteins, carbohydrates, vitamins, hormones, electrolytes, cellular wastes. Albumins- 60%, determine osmotic pressure (hold water in vessels) Hematopoietic stem cells- red bone marrow, source of blood cells. Erythrocytes, biconcave discs, no nucleus of mitochondria, (cid:1009),(cid:1004)(cid:1004)(cid:1004),(cid:1004)(cid:1004)(cid:1004) (cid:272)ells / l, transport oxygen. Hemoglobin: oxygen carrying molecule, 4 highly folded polypeptide chains, heme group contains iron which binds to oxygen. Erythropoietin (epo): hormone, controls rate of rbc production. Blood doping: increasing normal supply of red blood cells, delivers oxygen more efficiently (inject epo) Anemia: insufficient number of red blood cells (or lack of hemoglobin), pale and lack of energy. Damaged/ aged red blood cells rupture in spleen or liver. He(cid:373)e iro(cid:374) (cid:894)to (cid:271)lood(cid:895) a(cid:374)d (cid:271)iliverdin (become bilirubin- bile) Plasma membrane of red blood cells contains glycoproteins. Antigen: red blood cell surface molecule, self vs non-self. Antibodies: recognize antigens (against) produced to oppose blood type. Antibodies and antigens fit like lock and key. Agglutination: clumping of red blood cells from antibody/antigen interaction.
