VB SC 050S Lecture 25: Toxicology (lecture 24 and 25)
17 Nov 2016
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Document Summary
Toxicology: the study of the effects of poisons on the system. Forensic: classi cation of toxins are based on: Target organs (frequently liver, kidneys, nervous and/or reproductive tissue) Source (plant or animal: exogenous source, endogenous source. Chemistry (inorganic/oranic, amine, hydrocarbon, alkaloid, net valence structure) Margin of safety (dose that causes damage vs bene cial dose) Biochemical mechanism of action (how it works: factors affecting toxic response. Dose, chemical and physical properties of the compound, route of exposure, metabolism and excretion rates of the patient, age, sex and metabolic size of the patient: possible routes of exposure. Intravenous (in the veins: effects of toxins. Deleterious effect or toxic effects: severe effects that threaten life. Immediate effcts: occurs rapidly after a single dose. Delayed effects; occurs after a lapse of time, chemical is stored in the body, cellular change requires time: ex. cancer. Reversible: mild tissue damage can usually be repaired, neuronal and muscle may not.
