VB SC 050S Lecture Notes - Lecture 9: Hypoplasia, Cytopathic Effect, Fetus
8 Sep 2016
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Document Summary
A disease organism that persist in individuals and or populations. Organisms may persist by: evading usual inactivating inflammatory processes. Newly described disease of cattle reported in isolated infected herds, first described in 1946 in new york state. Ulcers of mucous membrane of gi system, decubital ulcer- the defect of epithelial cells. Virus: isolated in early 50s at cornell, identified as an rna virus, classified in the pestivirus genus of the family flaviviridae, blood test for antibodies developed, inability to isolate virus from a percentage of suspect cases. Virus could be there but not live/active. Rna viruses have very high mutation rates, more so than dna viruses. But doesn"t contribute to the inability to grow in live cultures. Cytopathic vs. non cytopathic: type 1. Mortality around 80-90: 4 possible causes. Type 1 cytopathic, type 1 non cytopathic, type 2 cytopathic, and type 2 non cytopathic: classic mucosal. As described on previous slide: persistent infection. Most cases do not show clinical signs.
