NROSCI 0081 Lecture Notes - Lecture 8: Therapeutic Index, Aspirin, Reuptake
Document Summary
Pharmocodynamics: study of biochemical and physiological effect of drug on body: how drugs effect your body, interaction of drug molecules with target tissue (receptors) Pharmacokinetics: absorption, distribution, metabolism, excretion (adme: how your body effects drug. Drug effect: alterations in physiological or psych function caused by molecular changes as a result of drug action, specific: therapeutic, side, nonspecific: set (psych makeup and expectation), setting (social and physical environment) 3rd basic principle of psychoactive drugs: magnitude, quality, diversity of a drug effects on the exposure. Pharmacodynamics: drug active site = synapse, drugs can have an effect on. Molecule that binds to a receptor is a ligand. Dose quantity of drug administered; usually expressed as drug/body weight. Some doses produce no effect (aspirin vs lsd) Maximal response highest achievable response of the drug. Ed50 = 50% of whatever max is, is being achieved.
