NROSCI 1030 Lecture Notes - Lecture 13: Adrenal Gland, Dopamine Hypothesis Of Schizophrenia, Chno-Fm
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It also decreased relapse by 65% - tremendous because it was very common. In 1963, arvid carlsson found that chloropromazine had a big increase in dopamine turnover. In a rat brain, there was much more dopamine release and metabolism: the drug worked by blocking dopamine receptors and allowing for more dopamine to be released. In, 1978, binding studies to show that when you look at anti-psychotic drug, an anti-psychotic drug displaced dopamine from the receptors: seemen if you ploted d2 kd versus clinical doase, this led to dopamine hypothesis. I(cid:374) other (cid:449)ords, (cid:449)he(cid:374) they ga(cid:448)e it you (cid:272)ould still feel the pai(cid:374), (cid:271)ut the pai(cid:374) did(cid:374)"t feel like it was being experienced by you: this is why you hear people self-mutilating on pcp. In a normal, glutamate will go to the channel open it and pcp will leave. If you look at a (cid:374)or(cid:373)al a(cid:374)d s(cid:272)hizophre(cid:374)i(cid:272) (cid:448)olu(cid:373)e, there is(cid:374)"t (cid:373)u(cid:272)h (cid:272)ha(cid:374)ge.
