BIOL 22100 Lecture Notes - Lecture 20: Tumor Necrosis Factor Superfamily, Innate Immune System, Mucous Membrane

• School: Purdue University
• Department: Biological Sciences
• Course: BIOL 22100
• Professor: Tom Walter

Document Summary

Innate consists of 3 features: physical barriers, white blood cells(granulocytes and phagocytes), Adaptive immunity has 2 features: humoral antibodies and cellular t cells. Talking about the innate immunity for this lecture. Your skin is very dry and bacteria need moisture to survive. Lactoferrin binds iron and keeps the iron concentration low since bacteria need iron for electron transport. Gamma delta t cells detect when skin is broken and bind to tight junctions to fill in the space. Mucous membranes trap bacteria and push it back out in the respiratory tract. All portals of entry are protected by mucous membranes other than broken skin. Granulocytes produce cytokines: polymorphonuclear because its nucleus is worm like. Cytokines are small proteins or peptides that function as communication molecules that signal one type of cell to do something when the cell receives the signal t varieties of cytokines: Chemokines-allow chemotaxis to site of infection (releases a signal for other cells to follow)