BIOL 22100 Lecture Notes - Lecture 21: Antigen-Presenting Cell, Golgi Apparatus, Adaptive Immune System

• School: Purdue University
• Department: Biological Sciences
• Course: BIOL 22100
• Professor: Tom Walter

Document Summary

Pamps bind to the prr to bring it into the phagocyte. This causes the phagocyte to produce cytokines and a costimulatory molecule. The production of cytokines recruit other cells (t cells) Once engulfed , pathogen is in a phagocytic vesicle. The phagosome then fuses with lysosomes to release digestive enzymes and oxidative burst and acid into the phagosome in order to kill the bacteria. Bacteria can fight this oxidative burst by producing antioxidants in order to neutralize it. They can also produce leukocidins to degrade the macrophage, capsules to prevent phagocytosis, and oxidants to kill the phagocyte. Unkilled bacteria become walled off inside a granuloma to encase it. Eventually this will kill the bacteria by cutting off blood supply. Some phagocytes are professional antigen presenting cells (apcs) The antigens that are digested out of the bacteria are displayed on a mhc protein and presented on the surface of the apc.