BIOL 22100 Lecture Notes - Lecture 27: Polymyxin B, Dna Gyrase, Vancomycin

• School: Purdue University
• Department: Biological Sciences
• Course: BIOL 22100
• Professor: Tom Walter

Document Summary

Therapeutic index is the toxic dose over the therapeutic dose. You want this index to be high, so you want a high toxic dose or low therapeutic dose. This index targets pathogen metabolism that we do not have-this is so it doesn"t kill us as well. Oral route of administration you just have to take a pill but. This antibiotic has to be absorbable through the bloodstream. This can also disrupt the native flora in the intestines. There are new generations of antibiotics that often are improved after each gen. Usually drug acts as a hapten to cause hs reactions. Toxicity can be another effect if the therapeutic index is low. This can cause rare side effects that are hard to predict. They can also suppress native flora and cause c. diff colitis like clindamycin. Antibiotics can also select for antibiotic resistant superbugs. Some example of these are mrsa and vre(vancomycin resistant)