BIO-1 Lecture Notes - Lecture 19: Lanosterol, Commensalism, Blood Culture
Document Summary
Rapid as do not have to wait for growth. Difficult to distinguish colonization versus infection if done on non-sterile. Pcr designed to detect specific target specimens. Most common fungal infection is caused by candida species. In the hospital, increasing importance as a cause of invasive candidiasis. Bloodstream infections with candida are the 3 4th most common in the intensive. Candida is a commensal in our gastrointestinal tract and genitourinary tract (urethra, Colonization oral mucosa in healthy people is 5 6% and increases in hospitalized care unit vagina) patient 13 75% Also found in the environment and can reside on surfaces (fomites) Often in intertriginous areas (e. g. under folds of skins) Chronic cutaneous disease seen in immunocompromised such as chronic granulomatous disease. Invasive candidiasis includes candidemia = candida in blood cultures. Also includes infection in organs such as liver, spleen, bone, central nervous system. Up to 47% attributable mortality for candidemia. Endogenous: factors that impact overgrowth in gut/mucosal surfaces.
