BIO-1 Lecture Notes - Lecture 22: Fonsecaea Pedrosoi, Giemsa Stain, Infliximab
Document Summary
Not specific to pcp, will also detect other fungal pathogens. Yeast or yeast-like form in host (37 degrees c) Most are endemic as usually reflect specific geographic areas. Mississippi and ohio rivers in us, south and central america. Early skin test studies: 80% positivity along endemic areas in us. Bird and bat droppings caving is a risk factor. Multiple infected nodes become matted, caseated necrosis. Fibrosis in response to caseation of lymph nodes in mediastinum. 2 4 um round to oval; single buds with narrow base. Artefactual clear zone that looks like capsule often seen in giemsa or wright stains. Variant duboisii yeast form is thick walled and larger (8 15 um); found in africa. Microconidia: 2 4 um, oval either sessile or on short stalks, seen initially (ddx. Macroconidia: 8 15 um thick-walled, usually tuberculate from blatomyces) The fourth most common cause of disseminated opportunistic infections with aids in. Thailland, southern china, and other parts of se asia.
