BIOL 01113 Lecture Notes - Lecture 2: Acetylcholine Receptor, Nicotinic Acetylcholine Receptor, Neurotransmitter Receptor
13 Dec 2017
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Remember the three main neurotransmitters: amino acids, amines, and peptides. In addition to the molecule itself, a neurotransmitter system includes all the molecular machinery responsible for transmitter synthesis, vesicular packaging, reuptake and degradation, and transmitter action. Cholinergic: describe the cells that produce and release aceylcholine (ach) Noradrenergic: neurons that use the amine neurotransmitter norepinephrine (ne) These adjectives are also used to identify the various neurotransmitter systems. Ex- ach and all the molecular machinery associated with it are collectively called the cholinergic system. Immunocytochemistry: used to anatomically localize particular molecules to particular cells. Once the neurotransmitter candidate has been chemically purified, it is injected under the skin or into the blood-stream of an animal where it stimulates an immune response. Once feature of the immune response is the generation of large proteins called antibodies. Anitbodies can bind tightly to specific sites on the foreign molecules, also known as the antigen in this case, the transmitter candidate.
