11:067:450 Lecture Notes - Lecture 3: G Protein–Coupled Receptor, Cyclic Adenosine Monophosphate, Thyrotropin-Releasing Hormone
4 Apr 2016
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Document Summary
Formation of degradation of cyclic adenosine monophosphate (cyclic amp) Cyclic amp has to be deactivated as soon as the signaling cascade is over and cyclic amp phosphodiesterase is responsible for the deactivation. Along with cyclic amp there could be cyclic gmp. Usually cyclic amp acts to open protein kinase a. Creb is a large family of proteins that may have a cyclic amp binding area. Cyclic amp may also bind to the carboxylic acid end of ( ) Inositol triphosphate (ip3) and diacylglycerol (dag): also second messengers. The g protein coupled receptor is an integral membrane protein that is embedded in the plasma membrane. There are many phospholipids at the cell membrane, such as the phospholipid bilayer. They make up the membrane and are associated with the membrane as well. Some of these phospholipids can be metabolized and converted into second messengers. Phospholipase c cleaves phosphatidylinositol-bis-phosphate (a second messenger) into ip3 and dag, which can also act as second messengers.
