11:115:301 Lecture Notes - Lecture 12: Anaerobic Respiration, Hexokinase, Lipid Bilayer

• School: Rutgers University
• Department: Biochemistry
• Course: 11:115:301
• Professor: Murphy

Document Summary

During a sprint glucose is oxidized to make atp at such a high rate insufficient. 6c sugar 3c pyruvate ethanol (yeast) or lactate (get rid of by heavy breathing) oxygen can be supplied. A universal catabolic pathway dating to a time before oxygen was plentiful. Normally when enough oxygen is present. Per glucose net gain of 2 atp and 2 nadh. Glucose (atp) glucose 6-phosphate fructose 6-phosphate (atp) fructose 1,6-bisphosphate. 3 irreversible kinase steps (1) glucose + atp --hexokinase--> glucose 6-phosphate + adp + h. 4 kcal/mol (3) fructose 6-phosphate + atp --phosphofructokinase--> fructose 1,6- bisphosphate + adp + h. 3. 4 kcal/mol (10) phosphoenolpyruvate + adp + h --pyruvate kinase--> pyruvate + atp: hexokinase (transferase), -4 kcal/mol, irreversible. 7. 5 kcal/mol: glucose + atp --hexokinase--> glucose 6-phosphate + adp + h, essentially irreversible, glucose enters the cell via glut glucose transport receptors, work in both directions.