11:115:301 Lecture Notes - Lecture 25: Aminoacyl-Trna, N-Terminus, Hypoxanthine
22 Sep 2019
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Document Summary
Bacterial chromosome 70s assembly of protein + rrna. Comprised of small 30s subunit + large 50s subunit. Business end = interface between both subunits. Rna passes between the 2 ribosomal subunits. 90 degrees perpendicular to path of mrna in the 50s subunit. Peptidyl transferase: process of moving the growing peptide chain onto a new amino- acyl trna. Does not use e use e making amino-acyl trna. Carbonyl of amino acid good lg. High e bond moves very easily. Putting in wrong amino acid like having a mutation. Frequency of inserting incorrect amino acid = 10^-5. A nucleotide to which the amino acid is attached. Base paired segments adopt double helical structure upside-down l. Extra arm more important in eukaryotes than in bacteria trna subject to modification. Modified cytidine that are found in them. The specifically-modified bases that define certain arms. Two arms acquire their name based on presence of specially modified bases. Nucleoside inosine base (pruine) = hypoxanthine.
