11:115:301 Lecture Notes - Lecture 20: Urea Cycle, Alanine Aminopeptidase, Protease
22 Sep 2019
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Document Summary
Humans can only synthesize some of the amino acids they need. 20 amino acids = building block of proteins. Majority of aa"s obtained by the hydrolysis of consumed proteins. Human adults can only synthesize 11 of them from basic compounds of intermediary metabolism. Essential amino acids in adult human beings: Essential amino acids aromatic, branchy, or weird. Single celled organisms (bacteria + yeast) can make all the amino acids they need. Consumed proteins digested by hydrolysis by proteases. Single aa"s, dipeptides, tripeptides absorbed by intestinal cells through transporters released into the blood by na+ anti-porters. Aa, tri- + dipeptides na+ antiporter blood. Cellular proteins are degraded when no longer needed. Macroscopic proteins need to be broken down. Proteins have a certain half-life in the cell. After degraded for the component parts. Urea formed from the degradation of amino acids. Urea cycle (4 intermediates): argin ine argininosucc inate ur ornithi ne.
