01:119:115 Lecture Notes - Lecture 18: Sickle-Cell Disease, Dominance (Genetics), Gel Electrophoresis
21 Jul 2019
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Document Summary
Treatment for disease - recently approved by the fda. Crispr - silences or inserts a gene into living cells: forensics. An individual"s unique dna sequence or genetic profile - obtained by analysis of tissue or body fluids. Dna testing can identify individuals with a high degree of certainty. Short tandem repeats (strs) - genetic markers identify different individuals in the same species. Gel electrophoresis ids str"s of different lengths. All humans have a different combination of str. Its difficult to study genetic variation in humans. Not a convenient organism for genetic studies. Dna sequencing - similarities and differences: pedigree analysis. Used by genetic counselors when a trait is controlled at a single locus. A genetic disorder is caused by an allele that causes a malfunctioning protein. Heterozygous is a normal phenotype but a carrier for that disorder. Most human genetic diseases are inherited as a single locus autosomal recessive trait. Autosomal - body chromosomes - 22 chromosomes.
