01:119:115 Lecture Notes - Lecture 15: Archibald Garrod, Neurospora Crassa, Nucleoside Triphosphate
22 Nov 2015
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Lagging strand: growing away from fork --> discontinuous fragments o o called okazaki fragments (later joined by dna ligase: summary of bacterial dna replication (figure 16. 17) *you can only build on the 3" side of dna. Dna --> synthesis of proteins --> specific traits --> genotype --> proteins. Translation a. b: genes are responsible for phenotypes. 1. link of 5"p to 3"oh group o sugar) o. Dna polymerases catalyze the elongation of new dna 5" to 3" direction: Nucleoside triphosphate --> building block = nucleoside (base plus a. Studied inherited diseases --> people unable to make particular enzyme. Suggested that genes responsible for phenotypes through enzymes o o. -> metabolic defects o that catalyze specific reactions o humans. One of the 1st to recognize that mendel"s principles of heredity apply to: one gene --> one enzyme hypothesis. Wild type: live on minimal medium (few nutrients)
