01:119:115 Lecture Notes - Lecture 1: Abiogenesis, Thiol, Heat Capacity
17 May 2016
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Adhesion: can go against gravity b/c sticks together. Moderate temperature: high specific heat & high heat of vaporization. Steps & conditions of abiogenesis according to oparin-haldane hypothesis (prebiotic soup: abiotic synthesis of monomers, formation of organic macromolecules, formation of protocells, appearance of self-replication, low free o2, energy source, building blocks, time. First cells (stromatolites) -> prokaryotes -> autotrophs -> cyanobacteria -> aerobes -> eukaryotes. Simple diffusion: only small, polar, neutral molecules. Carrier-mediated transport (can be p or a): Bulk transport: exocytosis: in -> out, endocytosis out -> in. Receptor-mediated: proteins in membrane bind to specific macromolecules. 1st: e cannot be created or destroyed, only converted between forms. Endergonic: storing energy; anabolic; making bonds; - g. Exergonic: releasing energy; catabolic; breaking bonds; + g. 2nd: every e transformation increases the universe"s entropy. Active site: binds with substrate (induced fit makes it change structure after binding) Low temp slows reaction; high temp denatures enzyme. Oxidizing agent gets reduced by accepting electrons.
