01:119:116 Lecture Notes - Lecture 12: Autocrine Signalling, Paracrine Signalling, Vasodilation

• School: Rutgers University
• Department: Biological Science
• Course: 01:119:116
• Professor: Christy Beal

Document Summary

Hormone ( from the greek to excite )= chemical messengers. Are secreted in body fluids (mostly blood) Travels through body bathing all cells > binds to a target cell. Target cell= any cell that has a receptor for the hormone. Receptor cell= has large glycoproteins/proteins on surface of cell. Cells receive too high of a signal= receptor-down. Cells receive too low of a signal = receptor-up: endocrine signaling, paracrine signaling, autocrine signaling, synaptic signaling, neuroendocrine signaling. Types of communication are classified into 5 paths. Local regulators can be: ex. cytokines, growth factor. Three major chemical classes of hormones: polypeptides, steroids- 4 carbon rings, cholesterol, fatty acids, gases, polypeptides ex. insulin ex. cortisol ex. prstoglandins ex. No (nitric oxide), vasodilator, (viagra: amines - from a single amino acid ex. epinephrine. This shape change catalyzes the conversion of atp of camp. Binds with proteins on outside of cell. Enters cell and binds with internal proteins.