01:119:131 Lecture Notes - Lecture 15: Isotretinoin, Streptococcus, Bacteriophage
9 Dec 2016
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Document Summary
Asymptomatic carriers, hospital personnel can often spread infections (50% adults nasal carriers) Gene to make this exotoxin can be found on: Scarlet fever rash caused by erythrogenic toxin (temperate phage) Prophage carried in toxin to this particular strain. That"s why not all strains have it bc not all strains have temperate phage that carries the toxin. Immunicomplication - rheumatic fever (heart muscle attacked) kidney glomeruli attacked. Antibody recognize something on kidneys so glomeruli is attacked. Makes hyaluronidase - can spread through lymphatics (skin tissue) Really is a streptococcal pyogene strain that has picked up this virulence factor called protease. Hyaluronidase, as it"s being secreted out of the cell, can travel through lymph tissue and have complications in circulations, causing damage in other areas of the body. Staphylococci or streptococci (combination of 2 or 3 organisms that cause lesions on skin, have to be treated) Acne - oily secretion on skin from sebaceous glands increase with increase of microorganism growth.
